MEK1/2 Recombinant Rabbit Monoclonal Antibody [SR13-07]

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

AA589381 antibody CFC3 antibody Dual specificity mitogen-activated protein kinase kinase 1 antibody Dual specificity mitogen-activated protein kinase kinase 2 antibody EC 2.7.12.2 antibody ERK activator kinase 1 antibody ERK activator kinase 2 antibody FLJ26075 antibody MAP kinase kinase 1 antibody MAP kinase kinase 2 antibody MAP2K1 antibody MAP2K2 antibody MAPK/ERK kinase 1 antibody MAPK/ERK kinase 2 antibody MAPKK 1 antibody MAPKK1 antibody MAPKK2 antibody MEK 1 antibody MEK1 antibody MEKK1 antibody Mitogen activated protein kinase kinase 1 antibody Mitogen activated protein kinase kinase 2 antibody Mitogen-activated protein kinase kinase 2, p45 antibody MK2 antibody MKK 1 antibody MKK 2 antibody MKK1 antibody MKK2 antibody MP2K1_HUMAN antibody PRKMK 1 antibody PRKMK 2 antibody Prkmk1 antibody Prkmk2 antibody protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) antibody Protein kinase, mitogen-activated, kinase 1 antibody Protein kinase, mitogen-activated, kinase 2 antibody

Abbreviation

MAP kinase kinase 1, MAPKK 1, MKK1, MEK 1, MAP kinase kinase 2, MAPKK 2, MEK 2

Swiss Prot

P36507 Human, Q02750 Human, P31938 Mouse, Q63932 Mouse, P36506 Rat, Q01986 Rat

Cellular Locus

Cytoplasm, Nucleus, Membrane, Mitochondrion

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Zebrafish

Immunogen

Recombinant protein within Human MEK1 aa 1-393 / 393.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, HepG2 cell lysate, A431 cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, PC-12 cell lysate, A549, NIH/3T3, human kidney tissue, mouse lung tissue, mouse kidney tissue, mouse hippocampus tissue, mouse brain tissue.