Cytokeratin 5+6 Mouse Monoclonal Antibody [A2A12]
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Product Specifications
Product Name Alternative
Abbreviation
CK-6A CK-6D K6A CK-6B K6B KRT6B CK-5 K5 KRT5
Swiss Prot
P02538 Human, P04259 Human, P13647 Human, Q6P6Q2 Rat, Q4FZU2 Rat
Cellular Locus
Cytoskeleton.
Host
Mouse
Species Reactivity
Human,Rat
Immunogen
Synthetic peptide within Human Cytokeratin 5 aa 340-380.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:5,000 ; ChICC/IHC-P:1:100-1:500 ; FC:1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 60/62 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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