AKR1C1 Mouse Monoclonal Antibody [5-F10]
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
20-alpha-HSD, DD1/DD2, HBAB, AKR1C1, DDH, DDH1
Swiss Prot
Q04828 Human
Cellular Locus
Cytoplasm.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human AKR1C1 aa 180-323 / 323.
Isotype
IgG2a
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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