PF-04822163

PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].

Product Specifications

CAS Number

[1798334-07-2]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-04822163.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C=CC2=C([C@H]3CCC4=C3C=C(Cl)C=C4)N=CN=C12

Molecular Formula

C19H17ClN2O2

Molecular Weight

340.80

References & Citations

[1]Humphrey J M, et al. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1[J]. MedChemComm, 2014, 5 (9) : 1290-1296.