Butenafine-13C, d3 (hydrochloride)

Butenafine-13C, d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

Product Specifications

Product Name Alternative

KP363-13C, d3 (hydrochloride)

UNSPSC

12352005

Target

Antibiotic; Fungal; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

CC(C)(C)C(C=C1)=CC=C1CN([13C]([2H])([2H])[2H])CC2=CC=CC3=C2C=CC=C3.Cl

Molecular Formula

C22 13CH25D3ClN

Molecular Weight

357.94

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Butenafine|[3]Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7.|[4]McNeely W, Spencer CM. Butenafine. Drugs. 1998 Mar;55 (3) :405-12; discussion 413.|[5]Singal A. Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008 Jul;4 (7) :999-1005.|[6]Syed TA, Maibach HI. Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 2000 Mar;1 (3) :467-73.