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INPP5F (OCRL) (NM_001587) Human Recombinant Protein

Product Specifications

Background

This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Synonyms

Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1; OCRL1

Gene ID

4952

UniProt

Q01968, A0A2X0TVZ9

Accession Number mRNA

NM_001587

Chromosomal Location

Xq26.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Field of Research

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

103 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

OCRL

Species

Human

Protein ID

NP_001578

Overview

Recombinant protein of human oculocerebrorenal syndrome of Lowe (OCRL), transcript variant b

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4952

Uniprot URL

https://www.uniprot.org/uniprot/Q01968

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001587

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001578

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