Elpipodect
Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a Ki value of 29 pM. Elpipodect can be used in research of schizophrenia[1].
Product Specifications
CAS Number
1424371-93-6
Product Name Alternative
MK-8189
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mk-8189.html
Purity
98.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(S1)=NN=C1CNC2=CC(OC[C@@H]3[C@@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2
Molecular Formula
C19H22N6OS
Molecular Weight
382.48
References & Citations
[1]Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66 (2) :1157-1171.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE10
Available Sizes
Frequently Asked Questions
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