Santacruzamate A
Ultrapotent HDAC2 inhibitor
Product Specifications
Background
Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively) (1). It induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors (2). It has been been investigated as a potential therapeutic agent for breast cancer (3). Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models (4).
CAS Number
1477949-42-0
Product Name Alternative
N-[4-Oxo-4-[ (2-phenylethyl) amino]butyl]-carbamic acid, ethyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Neuroscience | Neurodegeneration | Alzheimer's Disease
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml)
Molecular Formula
C15H22N2O3
Molecular Weight
278.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Pavlik C.M., et al. (2013) J. Nat. Prod. 76:2026
2.Zhou et al. H., (2018) Cell Prolif. 51(3):e12477
3. Damaskos C., et al. (2017) Anticancer Res. 37:35
4.Chen L., et al. (2019) Front. Cell. Neurosci. 13:61
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