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M2N12

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research[1].

Product Specifications

CAS Number

[2376577-06-7]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m2n12.html

Concentration

10mM

Purity

98.19

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 67°C)

Smiles

O=C(C(Cl)=C1NCC2=CN(CC3=CC=C(C)C=C3)N=N2)C4=C(N=CC=C4)C1=O

Molecular Formula

C20H16ClN5O2

Molecular Weight

393.83

References & Citations

[1]Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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