FITC Anti-Human CD8a Antibody[OKT-8]

Product Specifications

Background

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers) . CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Abbreviation

CD8

Gene ID

925

UniProt

P01732

Host

Mouse

Reactivity

Human

Target

CD8A; MAL; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2

Clonality

Monoclonal

Clone

OKT-8

Conjugation

FITC

Applications

FCM

Field of Research

Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://europepmc.org/article/med/37566545?javascript_support=no

Citation 02

https://www.sciencedirect.com/science/article/pii/S2211124719314159

Citation 03

https://www.nature.com/articles/s41388-024-03140-y

Citation 04

https://www.nature.com/articles/s41541-024-01060-2

Citation 05

https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.70005

Citation 06

https://www.sciencedirect.com/science/article/pii/S0002961020301501

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG2a, κ

Available Sizes

Documents

Product Datasheet

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