Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2, which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P27037-1

Expression Region

Ala 20 - Pro 135

Host

HEK293

Target

Activin RIIA

Conjugation

Unconjugated

Tag

N-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.4-25 ng/mL (QC tested).