NR1H3 antibody
Product Specifications
Background
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
Synonyms
Oxysterols receptor LXR-alpha|Liver X receptor alpha|Nuclear receptor subfamily 1 group H member 3|NR1H3|LXRA
Gene ID
10062
UniProt
Q13133
Host
Mouse
Reactivity
Human, Rat
Immunogen
nuclear receptor subfamily 1, group H, member 3
Target
NR1H3
Clonality
Monoclonal
Isotype
IgG2a
Clone
7D2
Applications
ELISA, WB, IF
Field of Research
Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:200-1:1000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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