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Human ADAM8 / CD156a Protein, His Tag

Human ADAM8, His Tag (AD8-H5223) is expressed from human 293 cells (HEK293) . It contains AA Ile 17 - Pro 497 (Accession # AAI15405.1) .

Product Specifications

Background

Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. ADAM8 / CD156a contains 1 disintegrin domain, 1 EGF-like domain and 1 peptidase M12B domain. ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes. ADAM8 / MS2 possible involvement in extravasation of leukocytes.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 53.8 kDa. Two main fragments bands are visible with apparent MW of 57-65 kDa and 35-40 kDa respectively in reduced SDS-PAGE as a result of its being prone to proteolytic cleavage.

Accession Number

AAI15405.1

Expression Region

Ile 17 - Pro 497

Host

HEK293

Target

ADAM8

Conjugation

Unconjugated

Tag

C-6xHis

Source

Human

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Format

Powder

Buffer

50 mM Tris, 150 mM NaCl, pH7.5

Additives

Trehalose

Molecular Weight

53.8 kDa

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

250ug*2

Product Datasheet

Https://www.acrobiosystems.com/static/main/products/pdf/ds/AD8-H5223.pdf

Species

Human

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