Ir-UA
Product Specifications
UNSPSC Description
Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot tumors." Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ir-ua.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(O)=C2C(C)(C(OC2=C1C(C)=O)=CC/3=O)C(C3=C(C)\NCC4=CC=[N](C(C5=[N]6C=CC(C)=C5)=C4)[Ir+3]786(C9=CC=CC=C9C%10=[N]8C=CC=C%10)[N]%11=CC=CC=C%11C%12=CC=CC=C%127)=O)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Weight
1171.11
References & Citations
[1]Deng D, et al. Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6810-6821.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162463/Ir-UA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162463/
Clinical Information
No Development Reported
CAS Number
3033235-42-3
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