Recombinant human IRF3 protein
Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. Recombinant human IRF3 was expressed in E. coli and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
IRF3, Interferon regulatory factor-3, IRF-3, Interferon regulatory factor 3, IRF 3.
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
13 kDa (112aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Pietila TE et al., J Immunol. (2007) 178 (1) :253-61; ; DeFilippis VR et al., J Virol., (2006) 80 (2) :1032-7;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-buffered saline (pH 7.4)
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001562.1
Uniprot Accession Number
Q14653
Species
Human
AA Sequence
MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS
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