(R) -Citalopram (oxalate)

(R) -Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R) -Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT) . (R) -Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R) -Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism[1].

Product Specifications

CAS Number

[219861-53-7]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

5-HT Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-citalopram-oxalate.html

Purity

99.52

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C(O)=O)=O.CN(C)CCC[C@@]1(C2=CC=C(C=C2)F)C3=CC=C(C#N)C=C3CO1

Molecular Formula

C22H23FN2O5

Molecular Weight

414.43

Precautions

H302, H312, H332

References & Citations

[1]Signe í Stórustovu, et al. R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter. Br J Pharmacol. 2004 May;142 (1) :172-80.|[2]Connie Sánchez, et al. The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol. 2006 Aug;99 (2) :91-5.