UK122

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM) . UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].

Product Specifications

CAS Number

[940290-58-4]

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/uk122.html

Purity

99.85

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N

Molecular Formula

C17H13N3O2

Molecular Weight

291.30

Precautions

H302, H400

References & Citations

[1]Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6 (4) :1348-56.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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