Amezinium (methylsulfate)

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptors Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25) . During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.

Product Specifications

CAS Number

[30578-37-1]

Product Name Alternative

Amezinium metilsulfate; Lu-1631

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Amezinium-methylsulfate.html

Purity

99.72

Solubility

DMSO : ≥ 34 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O

Molecular Formula

C12H15N3O5S

Molecular Weight

313.33

Precautions

H302

References & Citations

[1]Schaps D, et al. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19 (5) :235-9.