COMMD5 (NM_014066) Human Recombinant Protein

Product Specifications

Background

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237) . Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity) . Down-regulates activation of NF-kappa-B (PubMed:15799966) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human COMM domain containing 5 (COMMD5), transcript variant 1

Synonyms

HCARG; HT002

Gene ID

28991

UniProt

Q9GZQ3

Accession Number mRNA

NM_014066

Chromosomal Location

8q24.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

24.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.