S1R agonist 1

S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

Product Specifications

CAS Number

[193354-70-0]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s1r-agonist-1.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(OCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1

Molecular Formula

C20H25NO

Molecular Weight

295.42

References & Citations

[1]Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.