Bisphenol C

Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC50 values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on[1][2][3].

Product Specifications

CAS Number

[79-97-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Estrogen Receptor/ERR; mTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bisphenol-c.html

Purity

98.0

Smiles

CC1=CC(=CC=C1O)C(C)(C)C2=CC=C(C(=C2)C)O

Molecular Formula

C17H20O2

Molecular Weight

256.34

Precautions

H315, H319, H335

References & Citations

[1]Xiaohui Liu, et al. Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding. PLoS One. 2021 Feb 9;16 (2) :e0246583.|[2]Su K, et al. Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis. Environ Sci Technol. 2024 Oct 1;58 (39) :17259-17269. |[3]Liu J, et al. Bisphenol C induces developmental defects in liver and intestine through mTOR signaling in zebrafish (Danio rerio) . Chemosphere. 2023 May;322:138195.