CI 972 (anhydrous)

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].

Product Specifications

CAS Number

[115787-68-3]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ci-972-anhydrous.html

Solubility

10 mM in DMSO

Smiles

O=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl

Molecular Formula

C11H12ClN5OS

Molecular Weight

297.76

References & Citations

[1]Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4.|[2]Gilbertsen RB, et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178 (3) :1351-8.