AR244555
AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects[1].
Product Specifications
CAS Number
858350-62-6
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ar244555.html
Smiles
O=C(N1CC2(CCN(CCC=C)CC2)C3=C1C=CC(Cl)=C3)C4=C(F)C=CC=C4F
Molecular Formula
C23H23ClF2N2O
Molecular Weight
416.89
References & Citations
[1]Tong Zhang, et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302 (1) :H299-311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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