CCT251236

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.

Product Specifications

CAS Number

[1693731-40-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CCT251236.html

Purity

98.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(NC(C2=CC(OCCO3)=C3C=C2)=O)C=C1NC(C4=CC(C=CC(OCCN5CCCC5)=N6)=C6C=C4)=O

Molecular Formula

C32H32N4O5

Molecular Weight

552.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Cheeseman MD, et al. Discovery of a Chemical Probe Bisamide (CCT251236) : An OrallyBioavailable Efficacious Pirin Ligand from a Heat ShockTranscription Factor 1 (HSF1) Phenotypic Screen. J Med Chem. 2017 Jan 12;60 (1) :180-201.