MBD1 Recombinant Rabbit Monoclonal Antibody [PSH01-79]
MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
MBD1, CXXC3, PCM1
Swiss Prot
Q9Z2E2 Mouse, Q66HB8 Rat
Cellular Locus
Nucleus, Nucleus matrix, Nucleus speckle, Chromosome
Host
Rabbit
Species Reactivity
Mouse,Rat
Immunogen
Recombinant protein within mouse MBD1 aa 1-200 / 636.
Isotype
IgG
Clone
PSH01-79
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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