GSK180736A
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
Product Specifications
CAS Number
[817194-38-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
G Protein-coupled Receptor Kinase (GRK) ; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GSK180736A.html
Purity
98.81
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC=C(F)C=C4)NC1=O
Molecular Formula
C19H16FN5O2
Molecular Weight
365.36
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2; ROCK1
Available Sizes
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