Baicalin

Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3].

Product Specifications

CAS Number

[21967-41-9]

Product Name Alternative

Baicalein 7-O-β-D-glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HIV; NF-κB

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Baicalin.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C(O)C(O)=C3C(C=C(C4=CC=CC=C4)OC3=C2)=O

Molecular Formula

C21H18O11

Molecular Weight

446.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Lin M, et al. The protective effect of Baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis. BMC Complement Altern Med. 2014 Jan 13;14:19.|[2]Ju XN, et al. Baicalin protects against thrombin induced cell injury in SH-SY5Y cells. Int J Clin Exp Pathol. 2015 Nov 1;8 (11) :14021-7.|[3]Dai J, et al. Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A. 2018;115 (26) :E5896-E5905.