DOTA-PEG5-C6-DBCO
Product Specifications
UNSPSC Description
DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dota-peg5-c4-dbco.html
Solubility
DMSO : 125 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCCCC(NCCOCCOCCOCCOCCOCCNC(CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O
Molecular Weight
982.13
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-140314/DOTA-PEG5-C6-DBCO-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-140314/DOTA-PEG5-C6-DBCO-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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