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Masoprocol

Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].

Product Specifications

CAS Number

[27686-84-6]

Product Name Alternative

Meso-Nordihydroguaiaretic acid; meso-NDGA

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Lipoxygenase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/masoprocol.html

Purity

99.30

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(C=C1C[C@@H](C)[C@@H](C)CC2=CC(O)=C(C=C2)O)=C(C=C1)O

Molecular Formula

C18H22O4

Molecular Weight

302.36

Precautions

H302, H312, H332

References & Citations

[1]Luo J, et al. Masoprocol (nordihydroguaiaretic acid) : a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata) . Eur J Pharmacol. 1998 Apr 3;346 (1) :77-9.|[2]Reed MJ, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42 (1) :102-6.|[3]Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000 Sep;49 (9) :1106-10.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-109500/Masoprocol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-109500/Masoprocol-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

Launched

Available Sizes

Curated Selection

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