AZ-Dyrk1B-33
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].
Product Specifications
CAS Number
[1679330-37-0]
Product Name Alternative
(±)-Pirmenol (hydrochloride); CI-845,(±)-Pirmenol; CI-845 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/az-dyrk1b-33.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=C2C=CN=C4)=N1
Molecular Formula
C19H16N4
Molecular Weight
300.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58 (6) :2834-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
Available Sizes
Curated Selection
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