PD318088

PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295) . PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1].

Product Specifications

CAS Number

[391210-00-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PD318088.html

Purity

99.82

Solubility

DMSO : ≥ 100 mg/mL

Smiles

BrC1=CC(C(NOCC(CO)O)=O)=C(C(F)=C1F)NC2=CC=C(C=C2F)I

Molecular Formula

C16H13BrF3IN2O4

Molecular Weight

561.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11 (12) :1192-7.|[2]Han S, et al. Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15 (24) :5467-73.