ONO-AE 248
ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K (ATP) channels[1].
Product Specifications
CAS Number
[211230-67-0]
UNSPSC
12352211
Target
Endogenous Metabolite; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ono-ae-248.html
Purity
98.27
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCCCC[C@H](OC)/C=C/[C@@H]1[C@H](C(C[C@H]1OC)=O)C/C=C\CCCC(O)=O
Molecular Formula
C22H36O5
Molecular Weight
380.52
References & Citations
[1]Selective activation of the prostanoid EP (3) receptor reduces myocardial infarct size in rodents
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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