SR18662
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1].
Product Specifications
CAS Number
2505001-62-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
KLF
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sr18662.html
Purity
99.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=CC(/C=C/C(NCC(N2CCN(CC2)S(C)(=O)=O)=O)=O)=CC=C1Cl
Molecular Formula
C16H19Cl2N3O4S
Molecular Weight
420.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Julie Kim, et al.The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitroand In Vivo.Mol Cancer Ther.2019 Nov;18 (11) :1973-1984.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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