VU0400195
VU0400195 (ML182) is a oral active and allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with the EC50 of 291 nM. VU0400195 can be used for study of antiparkinsonian animal model[1][2].
Product Specifications
CAS Number
1309434-83-0
Product Name Alternative
ML182
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0400195.html
Smiles
O=C(C1=NC=CC=C1)NC2=CC=C(C(Cl)=C2)N3C([C@@]4([C@@]5([H])C[C@@]([H])([C@]4([H])C3=O)C=C5)[H])=O
Molecular Formula
C21H16ClN3O3
Molecular Weight
393.82
References & Citations
[1]Jones CK, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4- (2,5-dioxopyrrolidin-1-yl) phenylpicolinamides (VU0400195, ML182) : characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu (4) ) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54 (21) :7639-47. |[2]Darren W. Engers, et al. Discovery, Synthesis, and Preclinical Characterization of N- (3-Chloro-4-fluorophenyl) -1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) . ACS Chem. Neurosci. 2016, 7, 9, 1192–1200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
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