JNK-IN-16
JNK-IN-16 (MA43 or compound 3a) is a potent JNK and c-Met inhibitor with IC50s of 72 nM and 120 nM, respectively. JNK-IN-16 can be used for cancer[1][2].
Product Specifications
CAS Number
940057-42-1
UNSPSC
12352005
Target
C-Met/HGFR; JNK
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
99.82
Smiles
OC1=CC=C(C=C1)CC2=NN=C3N2N=C(C=C3)C4=CC=CC=C4
Molecular Formula
C18H14N4O
Molecular Weight
302.33
References & Citations
[1]Yu-Ping Yang, et al. Statistical molecular identification of kinase inhibitors to disrupt c-Jun N-terminal protein kinase involved in paraquat-mediated toxicological effects. Journal of Chemometrics. 2017; e2905.|[2]Brian K Albrecht, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008 May 22;51 (10) :2879-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK; Met
Available Sizes
Frequently Asked Questions
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