Agitoxin-2 (TFA)

Agitoxin-2 TFA is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively) [1][2].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/agitoxin-2-tfa.html

Solubility

H2O

Smiles

OC(C(F)(F)F)=O.O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]2CCCCN)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N4[C@@H](CCC4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]5CC6=CNC=N6)=O)NC2=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N7[C@@H](CCC7)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N8[C@@H](CCC8)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC9=CC=CC=C9)C(NCC(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C169H278N54O48S8.xC2HF3O2

Molecular Weight

4090.87 (free acid)

References & Citations

[1]M L Garcia, et al. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33 (22) :6834-9.|[2]Raveendra Anangi, et al. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.