Pyridoxal hydrochloride

Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744) . Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) [1][2][3].

Product Specifications

CAS Number

[65-22-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pyridoxal-hydrochloride.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=CC1=C(C=NC(C)=C1O)CO.Cl

Molecular Formula

C8H10ClNO3

Molecular Weight

203.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Vrolijk MF, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function[J]. Toxicol In Vitro. 2017 Oct;44:206-212.|[2]Aufiero E, et al. Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review[J]. Nutr Rev. 2004 Mar;62 (3) :96-104. |[3]Nagata Y, et al. Solvolysis of pyridoxal hydrochloride in alcohols[J]. Chemical and pharmaceutical bulletin, 1993, 41 (6) : 1019-1022.|[4]Vrolijk MF, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212.