UCM-13369
Product Specifications
UNSPSC Description
UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ucm-13369.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]([C@@H]1CCNCC2CC2)[C@@H](C3=CC=C(OC)C=C3)CC4=C1C5=C(N4)C=CC=C5
Molecular Weight
389.53
References & Citations
[1]Algar S, et al. Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia. JACS Au. 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162265/UCM-13369-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162265/
Clinical Information
No Development Reported
CAS Number
2921944-77-4
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