PTK7 / CCK4 Recombinant Protein
Product Specifications
Background
PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
CAS Number
9000-83-3
NCBI Gene ID
5754
Swiss Prot
Q13308
Accession Number
NP_002812.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
76.5 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.5 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Proteintyrosinekinase7 (inactive)
NCBI Organism
Homo sapiens
Background Reference 01
Won-Sik Shin, et al. Biochem Biophys Res Commun. 2008. 371 (4) :793-8.
Background Reference 02
Thomas Prebet, et al. Blood. 2010. 116 (13) :2315-23.
Background Reference 03
Vladislav S Golubkov, et al. J Biol Chem. 2010. 285 (46) :35740-9.
Other Product Names
PTK7, CCK4, CCK-4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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