RG14620

RG14620 is an EGFR inhibitor with an IC50 of 3 μM.

Product Specifications

CAS Number

[136831-49-7]

Product Name Alternative

Tyrphostin RG14620

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RG14620.html

Concentration

10mM

Purity

98.09

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

N#C/C(C1=CC=CN=C1)=C/C2=CC(Cl)=CC(Cl)=C2

Molecular Formula

C14H8Cl2N2

Molecular Weight

275.13

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Sagara Y, et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem. 2002 Sep 27;277 (39) :36204-15.|[2]Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51 (16) :4430-5.