APP/β-Amyloid Recombinant Rabbit Monoclonal Antibody [PSH04-90]
Amyloid beta precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein existing as several isoforms. The amino acid sequence of APP contains the amyloid domain (A-beta), which can be released by a two-step proteolytic cleavage. It is expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. APP acts as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It is also involved in cell mobility and transcription regulation through protein-protein interactions.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
APP, A4, AD1
Swiss Prot
P05067 Human, P12023 Mouse
Cellular Locus
Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within C-terminal human Amyloid Beta.
Isotype
IgG
Clone
PSH04-90
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:200-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 87 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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