Ruvonoflast
Ruvonoflast (NT-0796) is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. Ruvonoflast inhibits IL-1β release in human PBMC cells with an IC50 value of 0.32 nM. Ruvonoflast is an isopropyl ester that undergoes intracellular conversion to Ruvonoflast, the carboxylic acid active species. Ruvonoflast reverses high fat diet-induced obesity, systemic inflammation and astrogliosis in the diet-induced obesity mouse model. Ruvonoflast is promising for research of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis[1][2][3][4].
Product Specifications
CAS Number
2272917-13-0
Product Name Alternative
NT-0796
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nt-0796.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)OC([C@H](OC(NC1=C2C(CCC2)=CC3=C1CCC3)=O)CC4=NC=CC=N4)=O
Molecular Formula
C23H27N3O4
Molecular Weight
409.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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