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Vem-L-Cy5

Vem-L-Cy5 (compound 3), modified with the NIR fluorophore cyanine-5 (Cy5), is a Vemurafenib (HY-12057) -based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E, and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability, and inhibits cell growth of many types of cancer[1].

Product Specifications

CAS Number

[3057544-65-4]

UNSPSC

12352005

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vem-l-cy5.html

Purity

98.31

Solubility

DMSO : 50 mg/mL

Smiles

CC1(C)C(/C=C/C=C/C=C2N(CCCCCC(NCCOCCOCC(NC3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(CCC)=O)=C6F)=O)C5=C4)C=C3)=O)=O)C7=C(C=CC=C7)C/2(C)C)=[N+](C)C8=C1C=CC=C8.O=C([O-])C(F)(F)F

Molecular Formula

C63H68F5N7O9S

Molecular Weight

1194.31

References & Citations

[1]Barresi E, et al. A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells. Eur J Med Chem. 2023 Aug 5;256:115446.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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