Recombinant Human Cell adhesion molecule CEACAM1 (CEACAM1), partial (Active)
Product Specifications
Product Name Alternative
Cell adhesion molecule CEACAM1; Biliary glycoprotein 1; Carcinoembryonic antigen-related cell adhesion molecule 1; CD66a; CEACAM1; BGP
Abbreviation
Recombinant Human CEACAM1 protein, partial (Active)
Gene Name
CEACAM1
UniProt
P13688
Expression Region
35-428aa
Organism
Homo sapiens (Human)
Target Sequence
QLTTESMPFNVAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPG
Tag
C-terminal 10xHis-tagged
Type
Active Protein & In Stock Protein
Source
Yeast
Field of Research
Cancer
Relevance
Isoform 1 Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Isoform 8 Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Purity
Greater than 95% as determined by SDS-PAGE.
Activity
Yes
Bioactivity
Measured by its binding ability in a functional ELISA.Immobilized Human CEACAM1 at 2 μg/mL can bind Anti-CEACAM1 recombinant antibody (CSB-RA005157MA1HU) . The EC50 is 0.3677-0.4528 ng/mL.
Form
Lyophilized powder
Buffer
Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
45.3 kDa
References & Citations
Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells. Ebrahimnejad A., Flayeh R., Unteregger G., Wagener C., Bruemmer J. Exp. Cell Res. 260:365-373 (2000)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Product MSDS
https://www.cusabio.com/msds/12937656/
Protein Length
Partial
Available Sizes
Curated Selection
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