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FECH (NM_000140) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]

Synonyms

EPP; EPP1; FCE

Gene ID

2235

UniProt

P22830, Q7KZA3

Accession Number mRNA

NM_000140

Chromosomal Location

18q21.31

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Porphyrin and chlorophyll metabolism

Field of Research

Metabolic pathways, Porphyrin and chlorophyll metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

42.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FECH

Species

Human

Protein ID

NP_000131

Overview

Recombinant protein of human ferrochelatase (protoporphyria) (FECH), nuclear gene encoding mitochondrial protein, transcript variant 2

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2235

Uniprot URL

https://www.uniprot.org/uniprot/P22830

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000140

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000131

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