2-Ketoglutaric acid-13C

2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) [1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) [2][3].

Product Specifications

CAS Number

[108395-15-9]

Product Name Alternative

Alpha-Ketoglutaric acid-13C

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Tyrosinase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-ketoglutaric-acid-13c.html

Purity

97.94

Solubility

10 mM in DMSO

Smiles

OC(CCC([13C](O)=O)=O)=O

Molecular Formula

C4 13CH6O5

Molecular Weight

147.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[3]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.