L-Cystine (hydrochloride)

L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A) -induced apoptosis. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones[1][2][3][4][5][6]

Product Specifications

CAS Number

[34760-60-6]

UNSPSC

12352209

Hazard Statement

H314, H411

Target

Endogenous Metabolite; Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; ROS Kinase

Type

Peptides

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2r-2-r-3-3-disulfanediylbis-2-aminopropanoic-acid-hydrochloride.html

Purity

98.0

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

O=C([C@H](CSSC[C@@H](C(O)=O)N)N)O.Cl.Cl

Molecular Formula

C6H14Cl2N2O4S2

Molecular Weight

313.22

Precautions

H314, H411

References & Citations

[1]Abdullah M, et al. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors[J]. Biomol Ther (Seoul) . 2022 Mar 1;30 (2) :184-190. |[2]Kurihara S, et al. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine[J]. J Vet Med Sci. 2007 Dec;69 (12) :1263-70.|[3]Dominique Bazin, et al. Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale. Comptes Rendus. Chimie, Volume 25 (2022) no. S1, pp. 489-502. |[4]Greth WE, et al. Cellular accumulation of L-cystine in rat kidney cortex in vivo[J]. J Clin Invest. 1973 Feb;52 (2) :454-62.|[5]Ohtsu I, et al. Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. PLoS One. 2015 Apr 2;10 (3) :e0120619.|[6]Dai W, et al. Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture[J]. Cells. 2023 Jan 12;12 (2) :291.