Neomycin (sulfate) (Standard)

Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate) . This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis[1][2].

Product Specifications

CAS Number

[1405-10-3]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Phospholipase; Reference Standards

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/neomycin-sulfate-standard.html

Purity

99.87

Smiles

O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4]

Molecular Formula

C23H52N6O25S3

Molecular Weight

908.88

References & Citations

[1]Sasseville D. Neomycin. Dermatitis. 2010;21 (1) :3-7.|[2]Hu GF. Neomycin inhibits angiogenin-induced angiogenesis. Proc Natl Acad Sci U S A. 1998;95 (17) :9791-9795.|[3]Sasseville D. Neomycin. Dermatitis. 2010;21 (1) :3-7.|[4]Hu GF. Neomycin inhibits angiogenin-induced angiogenesis. Proc Natl Acad Sci U S A. 1998;95 (17) :9791-9795.