Antileishmanial agent-27
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs) . Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antileishmanial-agent-27.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=CC(OCC3=CC=C(Br)C=C3)=CC=C2C(CSC4=NC5=C(S4)C=CC=C5)=C1
Molecular Formula
C24H16BrNO3S2
Molecular Weight
510.42
References & Citations
[1]Nasim F, et al. Unraveling the peculiarities and development of novel inhibitors of leishmanial arginyl-tRNA synthetase. FEBS J. 2024 Mar 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
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