PROTAC BRM/BRG1 degrader-4

PROTAC BRM/BRG1 degrader-4 (example 047) is a potent BRM and BRG1 PROTAC degrader, with DC50 values of 0.21 nM and 3.4 nM in SW1573 cells, respectively (Pink: ligand for target protein (HY-168252) ; Black: linker (HY-28911) ; Blue: E3 ligase ligand (HY-168253) ) [1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-brm-brg1-degrader-4.html

Smiles

CNC(C1=C2C=C(C3=C(O)C=CC=C3)N=N1)=NN2C4CCN(CCOC5=NOC(C(C(N6C[C@H](O)C[C@H]6C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)C(C)C)=C5)CC4

Molecular Formula

C44H52N10O6S

Molecular Weight

849.01

References & Citations

[1]Peng Gu, et al. Brm selective degradation agent compound and use thereof. WO2023093728A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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