PROTAC BRM/BRG1 degrader-4
PROTAC BRM/BRG1 degrader-4 (example 047) is a potent BRM and BRG1 PROTAC degrader, with DC50 values of 0.21 nM and 3.4 nM in SW1573 cells, respectively (Pink: ligand for target protein (HY-168252) ; Black: linker (HY-28911) ; Blue: E3 ligase ligand (HY-168253) ) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brm-brg1-degrader-4.html
Smiles
CNC(C1=C2C=C(C3=C(O)C=CC=C3)N=N1)=NN2C4CCN(CCOC5=NOC(C(C(N6C[C@H](O)C[C@H]6C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)C(C)C)=C5)CC4
Molecular Formula
C44H52N10O6S
Molecular Weight
849.01
References & Citations
[1]Peng Gu, et al. Brm selective degradation agent compound and use thereof. WO2023093728A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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